Podcast

Moderator: Tin Chiu Li (Hong Kong)
Expert: Duru Shah (India)

Moderator: Clare Boothroyd (Australia)
Expert: Carlos Simon (Spain)

Moderator: Sures Nair (Singapore)
Expert: Jason Ho (Taiwan)

Progestin-primed ovarian stimulation (PPOS) is increasingly utilized in assisted reproductive technology (ART) for ovarian stimulation. Various progestins have been employed with comparable success. Studies indicate that the ovarian response to stimulation with PPOS is similar to that with gonadotrophin-releasing hormone (GnRH) analogues. Differences in the duration of stimulation or gonadotrophin consumption are minor and clinically insignificant. PPOS offers the advantages of oral administration and lower medication costs compared to GnRH analogues, making it a more cost-effective option for fertility preservation and planned freeze-all cycles. However, for fresh embryo transfer, PPOS may be less cost- effective depending on the local costs associated with the additional initial frozen embryo transfer cycle. Oocytes retrieved from PPOS cycles exhibit similar developmental potential, including comparable blastocyst euploidy rates. Frozen embryo transfer outcomes from PPOS and GnRH analogue cycles appear similar in terms of ongoing pregnancy/live birth rates and obstetric and perinatal outcomes. While some studies have reported lower cumulative live birth rates with PPOS, these studies have methodological limitations, such as arbitrary definitions of cumulative live birth rate. PPOS has been used successfully in all patient types, except for those with progesterone receptor-positive breast cancer, and appears to be a patient-friendly and cost-effective option if fresh embryo transfer is not planned.

Moderator: Clare Boothroyd (Australia)
Expert: Rupin Shah (India)

Moderator: Dr Clare Boothroyd (Australia)
Expert: Professor Claus Andersen (Denmark)

Moderator: Dr Keshav Malhotra (India)
Expert: Dr Jason Fransiak (USA)

The episode focuses on the nuanced interplay between euploid, aneuploid, mosaic, and segmental aneuploidy in embryos analyzed by Preimplantation Genetic Testing for Aneuploidy (PGT-A). We will explore the success rates of euploid pregnancies following the transfer of euploid embryos, highlighting the predictive value of PGT-A. The discussion extends to “mosaic” and “segmental aneuploid” embryos, examining the implications of these diagnoses and their management in clinical practice. We will delve into the origins of mosaic embryos and the challenges they present in decision-making processes. Additionally, the lecture will address the accuracy and inconsistencies of PGT-A testing platforms, shedding light on the impact of technological advancements on the interpretation of results. By providing an overview of the current landscape and emerging trends in PGT-A, this talk aims to equip participants with a deeper understanding of its role in enhancing reproductive outcomes.

Moderator: Professor Louise Hull (Australia)
Expert: Professor Kurt Barnhart (USA)

Moderator: Professor Arthur Chang (USA)
Expert: Dr Krishna Chaitanya Mantravadi (India)

In this episode of ASPIRE Ed Talk, host Professor Arthur Chang is joined by the guest Dr Krishna Chaitanya Mantravadi, to discuss the significant health challenges currently facing embryologists. Dr Krishna, an advocate for the wellness in the IVF laboratory, addresses the intense stress, high incidence of burnout, and the overall impact of these factors on physical and mental health within the field. Key topics include the demanding nature of the work despite its planned and elective character, the physical and mental health risks associated with the profession, and strategies for managing these challenges. Data from a survey reveal alarming rates of stress and burnout among professionals. The session emphasizes the importance of work-life balance, regular health check-ups, and institutional support to mitigate these issues. The discussion also covers necessary reforms in workplace practices and government policies to support the health and productivity of embryologists.

Moderator: Dr Duru Shah (India)
Expert: Dr Sonia Malik (India)

Every ART cycle whether Fresh or Frozen needs Luteal Support for it to be successful.

Moderator: Professor Rong Li
Expert: Professor Yangli Pang

The discussion focused on the relationship between gut dysbiosis and infertility, particularly in the context of polycystic ovary syndrome (PCOS). Gut dysbiosis, an imbalance in gut microbiota composition and function, is increasingly recognized as a contributing factor to infertility. Factors such as diet, medication, lifestyle, and disease conditions can disrupt the gut microbiota balance, leading to dysbiosis. Dysbiosis affects various aspects of reproductive health, including sperm quality in males and hormonal regulation in females, potentially leading to infertility and other reproductive disorders.

Moderator: Dr Somjate Manipalviratn (Thailand)
Expert: Professor Atsushi Tanaka (Japan)

Anaesthesia during ovum pick-up is a very unique scenario for anaesthesiologist as it involves very brief procedures in special circumstances. Much to discuss on the effect of anaesthesia on the gametes and also much to discuss on the supra-physiologic level of hormone on anaesthesia. This podcast is very special to have a guest speaker, Prof. Atsushi Tanaka, who is both a reproductive specialist as well as a certified anaesthesiologist.

Moderator: Prof. M. Louise Hull (Australia)
Expert: Prof. Gary Wittert (Australia)

On this ASPIRE EdTalk Podcast Professor Louise Hull will interview Endocrinologist Professor Gary Wittert from The University of Adelaide. They will discuss what doctors can look out for with regard to Adrenal Disorders and how to care for patients with Adrenal Disorders.

They will also explore questions like How do you distinguish PSOC and underlying adrenal disorder and what investigations are likely to be used.

Moderator: Dr. Madhuri Patil (India)
Expert: Dr. Shashank Joshi (India)

Both hyper and hypothyroidism can affect male and female fertility. Awareness of thyroid status in the infertile couple is crucial because of its significant, frequent, and reversible or preventable effect on infertility. The podcast aims to explore the intricate relationship between thyroid health and reproductive challenges. Our distinguished expert will illuminate the complexities, share invaluable insights, and address your inquiries, empowering us with knowledge to navigate this crucial nexus with greater understanding and efficacy. This interactive session is poised to uncover solutions and foster enhanced patient care in the realm of thyroid dysfunction and infertility in the couple.